I've recently downloaded the trial version of Zbrush to see what the difference is between it and Maya. At first I found it quite difficult to get used to the different interface but after a little while I got the hang of it. The main reason I wanted to try it out was to see if modelling my characters would be easier in this over Maya or Mudbox. I've only gotten the base mesh modelled so far which was a joy to do using Zspheres. I began the 'Introduction to Zbrush 4R7' course on Digital Tutors, starting off with just getting used to the interface, then onto basic sculpting and polypainting. The course show me how to use multiple tools such as Zspheres, Dynamesh and Zmodeler.